Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MLYCD | O95822 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16771934 | 0.84 | HDAC6 (0.53) | RAB9ANPC1HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL16771953 | 0.83 | HDAC6 (0.52) | HDAC6EGLN1TSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL16771954 | 0.83 | HDAC6 (0.52) | RAB9ANPC1HDAC6EGLN1TSHR | |
| SCHEMBL557803 | 0.82 | RAB9A (0.67) | RAB9ANPC1EGLN1TSHRHSD17B10 | |
| SCHEMBL16384871 | 0.82 | NPC1 (0.53) | RAB9ANPC1HDAC6TSHRHSD17B10 | |
| SCHEMBL16771874 | 0.82 | HDAC6 (0.51) | RAB9ANPC1HDAC6EGLN1SMN1; SMN2 | |
| SCHEMBL16771955 | 0.82 | HDAC6 (0.51) | RAB9ANPC1HDAC6EGLN1TSHR | |
| SCHEMBL16771902 | 0.82 | HDAC6 (0.51) | RAB9ANPC1HDAC6EGLN1TSHR | |
| SCHEMBL16771901 | 0.81 | HDAC6 (0.50) | RAB9ANPC1HDAC6EGLN1TSHR | |
| SCHEMBL16771899 | 0.80 | HDAC6 (0.49) | RAB9ANPC1HDAC6EGLN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079739-A2 | PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008041118-A2 | PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-04-10 | — | — | WO | disclosed |