Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971664 | 0.90 | SRC (0.47) | MKNK1HRH4FGFR1HTR2AHTR7 | |
| SCHEMBL3961990 | 0.89 | FGFR1 (0.49) | MKNK1FGFR1EGFRSRCFGFR2 | |
| SCHEMBL3970234 | 0.86 | MKNK1 (0.43) | MKNK1HRH4FGFR1PGK1EGFR | |
| SCHEMBL3969427 | 0.84 | IKBKB (0.53) | MKNK1HRH4FGFR1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL3961561 | 0.83 | IKBKB (0.52) | MKNK1HRH4FGFR1HTR2AHTR7 | |
| SCHEMBL3964652 | 0.83 | FGFR1 (0.45) | DRD2FGFR1TLR9TLR7HTR1A | |
| SCHEMBL3964419 | 0.83 | FGFR1 (0.50) | FGFR1PGK1EGFRSRCFGFR2 | |
| Hydrochloric Acid SCHEMBL3964159 | 0.82 | FGFR1 (0.44) | DRD2FGFR1TLR9TLR7HTR1A | |
| SCHEMBL3963258 | 0.79 | MKNK1 (0.46) | MKNK1ADRA1AADRA1DADRA1BHRH4 | |
| SCHEMBL4075976 | 0.77 | MKNK1 (0.45) | MKNK1ADRA1AADRA1DADRA1BHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |