Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.39 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3961990 | 0.90 | FGFR1 (0.49) | SRCMKNK1FGFR1EGFRFGFR2 | |
| SCHEMBL3958666 | 0.90 | MKNK1 (0.47) | SRCMKNK1FGFR1HRH4EGFR | |
| SCHEMBL3970234 | 0.87 | MKNK1 (0.43) | SRCMKNK1FGFR1HRH4EGFR | |
| SCHEMBL3969427 | 0.85 | IKBKB (0.53) | SRCMKNK1FGFR1HRH4EGFR | |
| Hydrochloric Acid SCHEMBL3961561 | 0.84 | IKBKB (0.52) | SRCMKNK1FGFR1HRH4EGFR | |
| SCHEMBL3963258 | 0.80 | MKNK1 (0.46) | SRCMKNK1FGFR1HRH4EGFR | |
| SCHEMBL4075976 | 0.78 | MKNK1 (0.45) | SRCMKNK1FGFR1HRH4EGFR | |
| SCHEMBL3970200 | 0.77 | FGFR1 (0.44) | SRCFGFR1EGFRFGFR2FGFR4 | |
| SCHEMBL3964652 | 0.77 | FGFR1 (0.45) | SRCFGFR1EGFRFGFR2FGFR4 | |
| SCHEMBL3962260 | 0.76 | IKBKB (0.50) | MKNK1CDK4GSK3BIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |