Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825820 | 1.00 | CRBN (0.40) | CRBNTSHRNPSR1DDB1POLB | |
| SCHEMBL278231 | 0.97 | CRBN (0.41) | CRBNTSHRNPSR1DDB1 | |
| SCHEMBL278097 | 0.87 | — | — | |
| SCHEMBL21049515 | 0.84 | CRBN (0.37) | CRBNTSHRNPSR1DDB1 | |
| SCHEMBL277887 | 0.78 | CRBN (0.48) | CRBNALDH1A1 | |
| SCHEMBL277992 | 0.78 | CRBN (0.48) | CRBNALDH1A1 | |
| SCHEMBL2732740 | 0.78 | CRBN (0.55) | CRBN | |
| SCHEMBL5435030 | 0.78 | CRBN (0.48) | CRBNTSHRALDH1A1 | |
| SCHEMBL278221 | 0.78 | CRBN (0.48) | CRBNALDH1A1 | |
| SCHEMBL785575 | 0.78 | CRBN (0.55) | CRBNTSHRNPSR1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086958-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | Purdue Pharma LP (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2009027820-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. (DE) | 2009-03-05 | — | — | WO | disclosed |