Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629649 | 0.84 | SREBF2 (0.42) | CYP19A1CDC25ACDC25BPRMT1GFER | |
| SCHEMBL13629628 | 0.84 | PIK3CA (0.48) | CYP19A1CDC25ACDC25BPRMT1GFER | |
| SCHEMBL3647330 | 0.82 | CDC25A (0.38) | CYP19A1CDC25ACDC25BPRMT1GFER | |
| SCHEMBL13057201 | 0.81 | PIK3CD (0.51) | CYP19A1CDC25ACDC25BPRMT1MEN1 | |
| SCHEMBL13615799 | 0.81 | PDE10A (0.38) | CYP19A1CDC25ACDC25BPRMT1MEN1 | |
| SCHEMBL20390796 | 0.80 | CDC25A (0.40) | CYP19A1CDC25ACDC25BPRMT1AXL | |
| SCHEMBL20390797 | 0.80 | MEN1 (0.50) | CYP19A1CDC25ACDC25BAXLPBRM1 | |
| SCHEMBL4308509 | 0.76 | CYP2E1 (0.46) | CYP19A1CDC25ACDC25BAXLPBRM1 | |
| SCHEMBL4308505 | 0.76 | CDC25A (0.39) | CYP19A1CDC25ACDC25BPRMT1AXL | |
| SCHEMBL12680158 | 0.73 | CDC25A (0.34) | CYP19A1CDC25ACDC25BPRMT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039177-A1 | 6, 11-BICYCLOIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2009-03-26 | — | — | WO | disclosed |