Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | CASP3 | P42574 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204602 | 0.76 | RAB9A (0.60) | RAB9ANPC1SENP7KDM4ECASP3 | |
| SCHEMBL19946528 | 0.76 | MAPT (0.59) | RAB9ANPC1SENP7KDM4ECASP3 | |
| SCHEMBL27606974 | 0.75 | MAPT (0.64) | RAB9ANPC1SENP7KDM4ECASP3 | |
| SCHEMBL6256451 | 0.75 | CA1 (0.60) | RAB9ANPC1SENP7KDM4ECASP3 | |
| SCHEMBL4031637 | 0.75 | RAB9A (0.65) | RAB9ANPC1SENP7KDM4ECASP3 | |
| SCHEMBL1641773 | 0.74 | IL2 (0.56) | RAB9ANPC1KDM4EKMT2AMEN1 | |
| SCHEMBL20773002 | 0.73 | MAPT (0.62) | RAB9ANPC1SENP7KDM4ECASP3 | |
| SCHEMBL11959269 | 0.73 | BRD4 (0.68) | RAB9ANPC1SENP7KDM4ECASP3 | |
| SCHEMBL11959273 | 0.73 | BRD4 (0.68) | RAB9ANPC1SENP7KDM4ECASP3 | |
| SCHEMBL2292344 | 0.73 | KDM4E (0.74) | RAB9ANPC1SENP7KDM4ECASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713465-A4 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2009-04-22 | — | — | EP | disclosed |
| EP-1713465-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005077122-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2005-08-25 | — | — | WO | disclosed |