SCHEMBL396108

SCHEMBL396108

CO[Si](CCCNC(=O)c1ccc2nc[nH]c2c1)(OC)OC

nearest known ligand 0.65

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.65
POLB P06746 7/20 0.65
TDP1 Q9NUW8 1/20 0.65
L3MBTL1 Q9Y468 2/20 0.58
NPC1 O15118 3/20 0.58
KMT2A Q03164 2/20 0.58
RAB9A P51151 2/20 0.58
HDAC6 Q9UBN7 2/20 0.56
CASP6 P55212 1/20 0.53
LMNA P02545 2/20 0.52
KDM4E B2RXH2 1/20 0.52
MAPT P10636 1/20 0.52
MAPK1 P28482 1/20 0.52
HDAC1 Q13547 1/20 0.52
NAMPT P43490 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL396107 0.91 POLB (0.53) HTTPOLBTDP1L3MBTL1NPC1
SCHEMBL30265138 0.88 HTT (0.68) HTTPOLBTDP1L3MBTL1NPC1
SCHEMBL30265199 0.85 HTT (0.71) HTTPOLBTDP1L3MBTL1NPC1
SCHEMBL30265129 0.84 HTT (0.69) HTTPOLBTDP1L3MBTL1NPC1
SCHEMBL30265294 0.83 HTT (0.67) HTTPOLBTDP1L3MBTL1NPC1
SCHEMBL23979000 0.82 HTT (0.74) HTTPOLBTDP1L3MBTL1NPC1
SCHEMBL30265168 0.82 HTT (0.67) HTTPOLBTDP1L3MBTL1NPC1
SCHEMBL30265382 0.82 HTT (0.67) HTTPOLBTDP1L3MBTL1NPC1
SCHEMBL30265336 0.81 HTT (0.66) HTTPOLBTDP1L3MBTL1NPC1
Hydrochloric Acid SCHEMBL30265084 0.81 HTT (0.66) HTTPOLBTDP1L3MBTL1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8101315-B2 Hybrid membranes, method for production of hybrid membranes and fuel cells using such hybrid membranes ELCOMAX MEMBRANES GMBH (DE) 2012-01-24 US disclosed
US-8101315-B2 Hybrid membranes, method for production of hybrid membranes and fuel cells using such hybrid membranes ELCOMAX MEMBRANES GMBH (DE) 2012-01-24 US disclosed
US-20090075141-A1 HYBRID MEMBRANES, METHOD FOR PRODUCTION OF HYBRID MEMBRANES AND FUEL CELLS USING SUCH HYBRID MEMBRANES ELCOMAX MEMBRANES GMBH (DE) 2009-03-19 US disclosed
US-20090075141-A1 HYBRID MEMBRANES, METHOD FOR PRODUCTION OF HYBRID MEMBRANES AND FUEL CELLS USING SUCH HYBRID MEMBRANES ELCOMAX MEMBRANES GMBH (DE) 2009-03-19 US disclosed