Dactinomycin

Dactinomycin

SCHEMBL3961092

Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O.O=P1(N(CCCl)CCCl)NCCCO1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GRB2 P62993 3/20 0.81
MAPT P10636 2/20 0.81
RECQL P46063 2/20 0.81
SMN1; SMN2 Q16637 2/20 0.81
ABCB11 O95342 1/20 0.81
ALDH1A1 P00352 1/20 0.81
CYP3A4 P08684 1/20 0.81
ALOX15 P16050 1/20 0.81
PTGS1 P23219 1/20 0.81
CASP1 P29466 1/20 0.81
HTT P42858 1/20 0.81
BLM P54132 1/20 0.81
CASP7 P55210 1/20 0.81
KMT2A Q03164 1/20 0.81
HIF1A Q16665 1/20 0.81
DDR2 Q16832 1/20 0.81
NGLY1 Q96IV0 1/20 0.81
HSD17B10 Q99714 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dactinomycin SCHEMBL13659669 0.90 GRB2 (1.00) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL27304406 0.90 GRB2 (1.00) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL26186613 0.90 GRB2 (1.00) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL3845 0.90 GRB2 (1.00) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL6152 0.90 GRB2 (1.00) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL19770615 0.90 GRB2 (1.00) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL6939686 0.90 GRB2 (1.00) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL3844 0.90 GRB2 (1.00) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL28168861 0.90 GRB2 (0.99) GRB2MAPTRECQLSMN1; SMN2ABCB11
Dactinomycin SCHEMBL2790145 0.90 GRB2 (0.99) GRB2MAPTRECQLSMN1; SMN2ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3328887-A1 ANTI-GM-CSF ANTIBODIES AND USES THEREOF I-MAB (KY) 2018-06-06 EP disclosed
EP-3325513-A1 ANTI-PD-L1 ANTIBODIES AND USES THEREOF I-MAB (KY) 2018-05-30 EP disclosed
WO-2018050111-A1 ANTI-GM-CSF ANTIBODIES AND USES THEREOF I-MAB (CN) 2018-03-22 WO disclosed
WO-2017215590-A1 ANTI-PD-L1 ANTIBODIES AND USES THEREOF I-MAB (CN) 2017-12-21 WO disclosed
WO-2017121320-A1 COMBINATION OF ACAT1 INHIBITOR AND CHECKPOINT ANTIBODY FOR TREATING CANCER SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES (CN) 2017-07-20 WO disclosed
WO-2017121318-A1 ACAT1 INHIBITORS FOR TREATING CANCER SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES (CN) 2017-07-20 WO disclosed
EP-2079486-A2 EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS The Board of Regents of The University of Texas System (US) 2009-07-22 EP disclosed
WO-2008045604-A2 EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2008-04-17 WO disclosed
EP-1888125-A2 POLY(PEPTIDE) AS A CHELATOR: METHODS OF MANUFACTURE AND USES Board of Regents of the University of Texas System (US) 2008-02-20 EP disclosed
EP-1846042-A2 CONJUGATES FOR DUAL IMAGING AND RADIOCHEMOTHERAPY: COMPOSITION, MANUFACTURING, AND APPLICATIONS Board of Regents, The University of Texas System (US) 2007-10-24 EP disclosed
WO-2006107794-A2 POLY(PEPTIDE) AS A CHELATOR: METHODS OF MANUFACTURE AND USES THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2006-10-12 WO disclosed
WO-2006074272-A2 CONJUGATES FOR DUAL IMAGING AND RADIOCHEMOTHERAPY: COMPOSITION, MANUFACTURING, AND APPLICATIONS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2006-07-13 WO disclosed