Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954572 | 0.89 | TRPV1 (0.53) | TRPV1MRGPRX4MAPK3MAOAKCNH2 | |
| SCHEMBL1863039 | 0.87 | TRPV1 (0.49) | TRPV1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1858042 | 0.86 | TRPV1 (0.41) | TRPV1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1860183 | 0.85 | TRPV1 (0.44) | TRPV1MRGPRX4MAPK3LRRK2 | |
| SCHEMBL1863373 | 0.84 | TRPV1 (0.46) | TRPV1MAPK3MAOAKCNH2 | |
| SCHEMBL1862939 | 0.84 | TRPV1 (0.38) | TRPV1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1859532 | 0.79 | TRPV1 (0.51) | TRPV1MAPK3MAOAKCNH2LMNA | |
| SCHEMBL3956119 | 0.78 | TRPV1 (0.64) | TRPV1MAPK3MAOAKCNH2GAA | |
| SCHEMBL12629652 | 0.78 | TRPV1 (0.68) | TRPV1MAPK3MAOAKCNH2 | |
| SCHEMBL1864536 | 0.76 | TRPV1 (0.49) | TRPV1MRGPRX4MAPK3MAOAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |
| EP-1811845-A4 | SUBSTITUTED BIARYL QUINOLIN-4-YLAMINE ANALOGUES | NEUROGEN CORP (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1811845-A2 | SUBSTITUTED BIARYL QUINOLIN-4-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006042289-A2 | SUBSTITUTED BIARYL QUINOLIN-4-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2006-04-20 | — | — | WO | disclosed |