Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | XDH | P47989 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | LOX | P28300 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786396 | 0.89 | MAPK14 (0.70) | MAPK14XDHMAPKAPK2PTPN1RIPK2 | |
| SCHEMBL3300932 | 0.88 | KMT2A (0.66) | MAPK14XDHKMT2AF2MAPKAPK2 | |
| SCHEMBL3296237 | 0.79 | PTPN1 (0.79) | MAPK14MAPKAPK2PTPN1RIPK2RAB9A | |
| SCHEMBL23723511 | 0.75 | RIPK2 (0.65) | MAPK14MAPKAPK2PTPN1RIPK2RAB9A | |
| SCHEMBL30120709 | 0.75 | RIPK2 (0.65) | MAPK14MAPKAPK2PTPN1RIPK2RAB9A | |
| SCHEMBL13799335 | 0.75 | XDH (0.57) | MAPK14XDHKMT2ARIPK2KDM4E | |
| SCHEMBL1692019 | 0.74 | RIPK2 (0.71) | MAPK14MAPKAPK2PTPN1RIPK2RAB9A | |
| SCHEMBL17877705 | 0.74 | KMT2A (0.61) | MAPK14XDHKMT2AF2KDM4E | |
| SCHEMBL544885 | 0.74 | KMT2A (0.71) | XDHKMT2AF2RIPK2KDM4E | |
| SCHEMBL30120645 | 0.74 | KMT2A (0.71) | XDHKMT2AF2RIPK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079702-A1 | 3-AMINO-PYRAZOLE-4-CARBOXAMIDE DERIVATIVES USEFUL AS INHIBITORS OF PROTEIN KINASES | Novartis AG (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008052974-A1 | 3-AMINO-PYRAZOLE-4-CARBOXAMIDE DERIVATIVES USEFUL AS INHIBITORS OF PROTEIN KINASES | NOVARTIS AG (CH) | 2008-05-08 | — | — | WO | disclosed |