Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967477 | 0.81 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL966876 | 0.71 | SMN1; SMN2 (0.37) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL965834 | 0.65 | NPC1 (0.44) | SMN1; SMN2NPC1RAB9AALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL967476 | 0.64 | NPC1 (0.43) | SMN1; SMN2NPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL13850881 | 0.63 | EGFR (0.35) | MAPTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL13850888 | 0.60 | EGFR (0.36) | MAPTALDH1A1TSHRHTTGAA | |
| SCHEMBL823385 | 0.59 | NR1H4 (0.44) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14140248 | 0.59 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL965895 | 0.58 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL26005529 | 0.58 | L3MBTL1 (0.70) | SMN1; SMN2NPC1RAB9AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622615-A4 | NAPHTHYRIDINE INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1622615-A2 | NAPHTHYRIDINE INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004101512-A2 | NAPHTHYRIDINE INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |