Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567016 | 0.91 | TSHR (0.52) | KMT2ATSHRMEN1CYP2C9CYP2C19 | |
| SCHEMBL1521876 | 0.86 | KMT2A (0.48) | KMT2ATSHRMEN1CYP2C9CYP2C19 | |
| SCHEMBL2567248 | 0.83 | KMT2A (0.46) | KMT2ATSHRMEN1CYP2C9CYP2C19 | |
| SCHEMBL3828694 | 0.83 | ATM (0.35) | KMT2AMEN1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21558450 | 0.82 | ATM (0.44) | TSHRALDH1A1NPC1LMNASMN1; SMN2 | |
| SCHEMBL21866062 | 0.81 | KMT2A (0.44) | KMT2ATSHRMEN1CYP2C9CYP2C19 | |
| SCHEMBL2649492 | 0.81 | HSP90AA1 (0.46) | KMT2ATSHRMEN1CYP2C9CYP2C19 | |
| SCHEMBL5267090 | 0.80 | KDM4E (0.50) | KMT2ATSHRMEN1ALDH1A1POLB | |
| SCHEMBL3913326 | 0.79 | ALDH1A1 (0.53) | KMT2ATSHRMEN1CYP2C9CYP2C19 | |
| SCHEMBL9590155 | 0.79 | KMT2A (0.42) | KMT2ATSHRMEN1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008038251-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-04-03 | — | — | WO | disclosed |