Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9415849 | 0.80 | IKBKB (0.44) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL3244658 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL11389056 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL19001490 | 0.74 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL276035 | 0.70 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL9934343 | 0.69 | KDM4E (0.46) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL31115164 | 0.69 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL5483645 | 0.69 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL11400875 | 0.68 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL17506376 | 0.68 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009037302-A1 | 5-SUBSTITUTED-1, 4-BENZ0DIAZEPINES AS PHOSPHODIESTERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2009-03-26 | — | — | WO | disclosed |
| US-6559141-B2 | Inhibit beta-amyloid peptide release and/or synthesis, use in treating Alzheimer's disease; for example, 5-(N'-(phenylacetyl)-L-alpha-(2-thienyl)glycinyl)-amino-7-methyl-5,7-dihydro-6H-dibenz(b, d)azepin-6-one | ATHENA NEUROSCIENCES, INC. | 2003-05-06 | — | — | US | disclosed |