Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LGMN | Q99538 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3539479 | 0.93 | KDM4E (0.47) | KDM4EMAPTGAAMAPK1HTT | |
| SCHEMBL3538621 | 0.90 | CSF1R (0.51) | KDM4EMAPTGAAMAPK1HTT | |
| SCHEMBL3541971 | 0.87 | CSF1R (0.55) | KDM4EMAPTGAAMAPK1HTT | |
| SCHEMBL3534452 | 0.85 | ALDH1A1 (0.56) | KDM4EMAPTGAAMAPK1HTT | |
| Hydrochloric Acid SCHEMBL3539657 | 0.84 | ALDH1A1 (0.55) | KDM4EMAPTGAAMAPK1HTT | |
| SCHEMBL3545551 | 0.81 | MAPT (0.82) | KDM4EMAPTGAAMAPK1HTT | |
| Trifluoroacetic Acid SCHEMBL3545922 | 0.81 | ALDH1A1 (0.49) | KDM4EMAPTGAAMAPK1HTT | |
| Trifluoroacetic Acid SCHEMBL3539482 | 0.79 | MAPT (0.64) | KDM4EMAPTGAAMAPK1HTT | |
| SCHEMBL27997684 | 0.79 | PARP1 (0.51) | KDM4EMAPTGAAMAPK1HTT | |
| SCHEMBL3540352 | 0.79 | ALDH1A1 (0.53) | MAPTGAAJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807407-B1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-29 | — | — | EP | claimed |