Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | NR4A2 | P43354 | 8/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309068 | 0.86 | PARP1 (0.58) | PLA2G4BKMT2A | |
| SCHEMBL12411431 | 0.83 | KMT2A (0.66) | PLA2G4BKMT2ANR4A2NR1H4AKR1C3 | |
| SCHEMBL29505938 | 0.83 | KMT2A (0.75) | PLA2G4BKMT2ANR4A2NR1H4AKR1C3 | |
| SCHEMBL29505934 | 0.83 | KMT2A (0.75) | PLA2G4BKMT2ANR4A2NR1H4AKR1C3 | |
| SCHEMBL10167730 | 0.83 | NR4A2 (0.65) | PLA2G4BKMT2ANR4A2AKR1C3NR4A1 | |
| SCHEMBL1333545 | 0.83 | KMT2A (0.75) | PLA2G4BKMT2ANR4A2NR1H4AKR1C3 | |
| Hydrochloric Acid SCHEMBL30608606 | 0.81 | KMT2A (0.73) | PLA2G4BKMT2ANR4A2NR1H4AKR1C3 | |
| SCHEMBL6816376 | 0.81 | KMT2A (0.63) | PLA2G4BKMT2ANR4A2NR1H4NR4A1 | |
| SCHEMBL464497 | 0.81 | ALOX15 (0.63) | PLA2G4BKMT2ANPC1RAB9A | |
| SCHEMBL874138 | 0.81 | KMT2A (0.62) | PLA2G4BKMT2ANR4A2NR1H4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008038251-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-04-03 | — | — | WO | disclosed |