Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 4/20 | 0.38 |
| ▸ | CRY1 | Q16526 | 4/20 | 0.38 |
| ▸ | CRY2 | Q49AN0 | 4/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 8/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951329 | 1.00 | PER2 (0.38) | PER2CRY1CRY2HTR4SLC6A9 | |
| SCHEMBL3038336 | 1.00 | PER2 (0.38) | PER2CRY1CRY2HTR4SLC6A9 | |
| SCHEMBL3039028 | 1.00 | PER2 (0.38) | PER2CRY1CRY2HTR4SLC6A9 | |
| SCHEMBL17162473 | 1.00 | PER2 (0.38) | PER2CRY1CRY2HTR4SLC6A9 | |
| SCHEMBL2913695 | 0.87 | — | — | |
| SCHEMBL17162480 | 0.87 | — | — | |
| SCHEMBL2985550 | 0.87 | — | — | |
| SCHEMBL17162469 | 0.87 | — | — | |
| SCHEMBL2911929 | 0.87 | — | — | |
| SCHEMBL2909263 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735304-B1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE INC (US) | 2009-01-07 | — | — | EP | claimed |