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PER2

Period circadian protein homolog 2 · O15055 · PER2 on Sugi Atlas →

8,421 patent compounds predicted against PER2, 2,541 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL9004363 SCHEMBL9004363 0.52 20/20
SCHEMBL2151617 SCHEMBL2151617 0.42 14/20
SCHEMBL3922170 SCHEMBL3922170 0.34 14/20
SCHEMBL734385 SCHEMBL734385 0.43 13/20
SCHEMBL8819173 SCHEMBL8819173 0.58 12/20
SCHEMBL607629 SCHEMBL607629 0.48 12/20
SCHEMBL608303 SCHEMBL608303 0.49 11/20
SCHEMBL8488753 SCHEMBL8488753 0.51 10/20
SCHEMBL8134208 SCHEMBL8134208 0.49 9/20
SCHEMBL2151350 SCHEMBL2151350 0.41 9/20
SCHEMBL7078510 SCHEMBL7078510 0.38 9/20
SCHEMBL8143242 SCHEMBL8143242 0.48 8/20
SCHEMBL609221 SCHEMBL609221 0.44 8/20
SCHEMBL5797737 SCHEMBL5797737 0.44 8/20
SCHEMBL4137380 SCHEMBL4137380 0.39 8/20
SCHEMBL8282938 SCHEMBL8282938 0.39 8/20
SCHEMBL8282939 SCHEMBL8282939 0.39 8/20
SCHEMBL4493928 SCHEMBL4493928 0.35 8/20
SCHEMBL9844700 SCHEMBL9844700 0.33 8/20
SCHEMBL2198451 SCHEMBL2198451 0.54 7/20

Clinical trials — most relevant to PER2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers PHASE3COMPLETED
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar PHASE2/PHASE3UNKNOWN
NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals PHASE2RECRUITING
Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health PHASE2RECRUITING
Biological Clock Dysfunction in Optic Nerve Hypoplasia EARLY_PHASE1COMPLETED
Circadian Rhythms and Sleep in Familial DSPS and ASPS nanCOMPLETED
Sleep, Obesity and Mental Disease - Biological Markers for the Evaluation of Circadian Rhythmicity nanUNKNOWN
Study of Circadian Clock Properties in Healthy Subjects, Obese and Type 2 Diabetic Patients. nanUNKNOWN
Restoring Molecular Circadian Rhythm nanSUSPENDED
Pilot Study of the Effects of Circadian Rhythms on the Treatment of Bipolar I Depression. nanWITHDRAWN
Biomarkers for Epilepsy Development and the Effect of Physical Exercise in Children With Autism nanCOMPLETED
Circadian Clock Gene Expression in Periodontal Disease nanCOMPLETED
Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic Uncoupling nanNOT_YET_RECRUITING
Melatonin Receptor Agonist and Peripheral Biological Markers nanCOMPLETED
Metabolic Investigation, Physical Performance, Physical Training At Different Times of the Day in Obese Women nanACTIVE_NOT_RECRUITING
The Role of Circadian Clock Proteins in Innate and Adaptive Immunity nanRECRUITING
Circadian Rhythm Disruption Effects on Smoke Inhalation nanCOMPLETED
Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, SIDERALE nanRECRUITING
Circadian Rhythm in Critical Illness nanCOMPLETED
Mapping the Shift Worker's Microbiome nanACTIVE_NOT_RECRUITING
Identification of Novel Circadian Biomarkers nanCOMPLETED
Metabolic Clock Genes During Fasting and After Food Intake in Type 2 Diabetics nanUNKNOWN
The Clinical Research on the Relationship Between Circadian Rhythm and Gut Microbiota in TBI Patients nanUNKNOWN
The Influence of Time-Restricted Eating in Patients With Metabolic Syndrome nanUNKNOWN
PER3 Clock Gene Polymorphism, Clock Gene Expression and Delirium in the Intensive Care Unit. nanWITHDRAWN
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption nanNOT_YET_RECRUITING
Effect of Liraglutide on Clock Genes nanUNKNOWN
Light Sensitization Study nanCOMPLETED
The Effect of Exercises Performed According to Circadian Rhythm in Type 2 Diabetes nanCOMPLETED
Efficacy Study of Light Therapy as an Adjunctive Treatment for Parkinson's Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PER2 binder may also engage these)

ProteinNameSimilarity
O70361 — 1.000 O70361 →
O54943 — 1.000 O54943 →
Q8K3T3 — 0.998 Q8K3T3 →
Q8CJE2 — 0.998 Q8CJE2 →
Q8K3T2 — 0.997 Q8K3T2 →
Q9Z301 — 0.997 Q9Z301 →
Q8CHI5 — 0.996 Q8CHI5 →
Q9JHS1 — 0.996 Q9JHS1 →
Q8QGQ8 — 0.994 Q8QGQ8 →
E1BE02 — 0.993 E1BE02 →
P56645 — 0.993 P56645 →
P97460 — 0.992 P97460 →
P41738 — 0.992 P41738 →
Q8R4S4 — 0.992 Q8R4S4 →
Q8R4S2 — 0.992 Q8R4S2 →
Q9H329 — 0.992 Q9H329 →
NR4A1 Nuclear receptor subfamily 4immunitygroup A member 1 0.992 landscape →
Q8R4S5 — 0.992 Q8R4S5 →
Q8R4S6 — 0.992 Q8R4S6 →
Q99NE9 — 0.992 Q99NE9 →
A7MBB4 — 0.991 A7MBB4 →
Q60610 — 0.991 Q60610 →
Q28F43 — 0.991 Q28F43 →
Q8IZQ8 — 0.991 Q8IZQ8 →
A0MLS5 — 0.991 A0MLS5 →
P79778 — 0.991 P79778 →
Q28DE6 — 0.991 Q28DE6 →
Q9N1U3 — 0.991 Q9N1U3 →
O97775 — 0.991 O97775 →
Q61501 — 0.991 Q61501 →