Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.49 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29396266 | 0.82 | KEAP1 (0.55) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| SCHEMBL449212 | 0.82 | KEAP1 (0.55) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| SCHEMBL15108064 | 0.80 | KEAP1 (1.00) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| Hydrochloric Acid SCHEMBL8118011 | 0.80 | KEAP1 (0.53) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| SCHEMBL4090066 | 0.79 | KEAP1 (0.50) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| SCHEMBL21870755 | 0.79 | KEAP1 (0.50) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| SCHEMBL1335286 | 0.77 | KEAP1 (0.67) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| SCHEMBL12990378 | 0.77 | KEAP1 (0.67) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| SCHEMBL5965425 | 0.77 | KEAP1 (0.67) | KEAP1NFE2L2NR3C1PGRNR3C2 | |
| SCHEMBL13869170 | 0.76 | KEAP1 (0.65) | KEAP1NFE2L2NR3C1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988022-B1 | HAIR DYE | HENKEL KGAA (DE) | 2005-09-21 | — | — | EP | claimed |
| US-20010004779-A1 | Novel p-aminophenol derivatives and the use thereof | ROSE DAVID (DE) | 2001-06-28 | — | — | US | claimed |
| EP-1044185-A2 | NEW DERIVATIVES OF P-AMINOPHENOL AND THEIR USE | Henkel Kommanditgesellschaft auf Aktien (DE) | 2000-10-18 | — | — | EP | claimed |
| EP-0988022-A1 | HAIR DYE | Henkel Kommanditgesellschaft auf Aktien (DE) | 2000-03-29 | — | — | EP | claimed |
| WO-1999060992-A1 | DIRECT HAIR DYE AND THE USE THEREOF | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1999-12-02 | — | — | WO | claimed |
| WO-1999031054-A2 | NOVEL P-AMINOPHENOL DERIVATIVES AND THE USE THEREOF | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1999-06-24 | — | — | WO | claimed |
| WO-1999007334-A1 | HAIR DYE | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1999-02-18 | — | — | WO | claimed |
| EP-1363876-B1 | GLUCOCORTICOID RECEPTOR MODULATORS | KAROBIO AB (SE) | 2009-07-29 | — | — | EP | disclosed |
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| EP-1231889-B1 | DIRECT HAIR DYES AND USE THEREOF | HENKEL KGAA (DE) | 2005-12-14 | — | — | EP | disclosed |
| EP-0988022-B1 | HAIR DYE | HENKEL KGAA (DE) | 2005-09-21 | — | — | EP | disclosed |
| EP-1218344-B1 | OXIDATION COLORANT STARTING PRODUCTS | HENKEL KGAA (DE) | 2005-08-17 | — | — | EP | disclosed |
| EP-1212032-B1 | NEW DIRECT HAIR COLORANTS | HENKEL KGAA (DE) | 2005-05-04 | — | — | EP | disclosed |
| US-6057349-A | ALPHA.SUB.1A/1L AGONISTS USED IN THE TREATMENT OF VARIOUS DISEASE STATES SUCH AS URINARY INCONTINENCE, NASAL CONGESTION, PRIAPISM, DEPRESSION, ANXIETY, DEMENTIA, SENILITY, ALZHEIMER'S, DEFICIENCIES IN ATTENTIVENESS AND COGNITION, AND | F. HOFFMAN LA ROCHE AG (CH) | 2000-05-02 | — | — | US | disclosed |
| EP-0988022-A1 | HAIR DYE | Henkel Kommanditgesellschaft auf Aktien (DE) | 2000-03-29 | — | — | EP | disclosed |
| WO-1999060992-A1 | DIRECT HAIR DYE AND THE USE THEREOF | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1999-12-02 | — | — | WO | disclosed |
| US-5952362-A | INHIBITOR OF GLYCOGEN PHOSPHORYLASE ENZYMETIC ACTIVITY AND GLUCOSE ACITIVITY | SYNTEX (U.S.A) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| WO-1999031054-A2 | NOVEL P-AMINOPHENOL DERIVATIVES AND THE USE THEREOF | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1999-06-24 | — | — | WO | disclosed |
| WO-1999007334-A1 | HAIR DYE | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1999-02-18 | — | — | WO | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010004779-A1 | Novel p-aminophenol derivatives and the use thereof | KRT18, S100P, CKAP4 | KEAP1 460/4885NFE2L2 1956/4885NR3C1 3629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.