Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962814 | 0.88 | GSK3B (0.42) | GSK3BLATS1KDM5B | |
| SCHEMBL3959225 | 0.86 | CYP2C9 (0.37) | GSK3BKDM5BCYP1A2CYP2D6 | |
| SCHEMBL4865548 | 0.83 | GSK3B (0.46) | GSK3BLATS1KDM5B | |
| SCHEMBL4476686 | 0.83 | KDM4E (0.46) | GSK3B | |
| SCHEMBL4872195 | 0.78 | GSK3B (0.41) | GSK3BKDM5B | |
| SCHEMBL315643 | 0.78 | GSK3B (0.44) | GSK3BKDM5BCYP2D6 | |
| Hydrochloric Acid SCHEMBL6883945 | 0.77 | GSK3B (0.45) | GSK3BKDM5BCYP2D6 | |
| Hydrochloric Acid SCHEMBL6883926 | 0.77 | GSK3B (0.45) | GSK3BKDM5BCYP2D6 | |
| SCHEMBL4416230 | 0.76 | LATS1 (0.43) | GSK3BLATS1KDM5B | |
| SCHEMBL315379 | 0.75 | GSK3B (0.52) | GSK3BCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081938-A2 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO Ý1,2-A¨PIRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDI NYL-PYRIMIDOÝ1,2,-A¨PYRIMIDIN-6-ONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008056266-A2 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO [1,2-A]PYRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDINYL-PYRIMIDO[1,2-A]PYRIMIDIN-6-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-05-15 | — | — | WO | disclosed |