Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962773 | 0.88 | GSK3B (0.43) | GSK3BLATS1KDM5B | |
| SCHEMBL3959225 | 0.85 | CYP2C9 (0.37) | GSK3BCDC7KDM5B | |
| SCHEMBL4476686 | 0.80 | KDM4E (0.46) | GSK3BCDC7 | |
| SCHEMBL4865548 | 0.80 | GSK3B (0.46) | GSK3BLATS1CDC7KDM5B | |
| SCHEMBL315643 | 0.79 | GSK3B (0.44) | GSK3BKDM5B | |
| Hydrochloric Acid SCHEMBL6883945 | 0.78 | GSK3B (0.45) | GSK3BKDM5B | |
| Hydrochloric Acid SCHEMBL6883926 | 0.78 | GSK3B (0.45) | GSK3BKDM5B | |
| SCHEMBL4872195 | 0.77 | GSK3B (0.41) | GSK3BCDC7KDM5B | |
| SCHEMBL4416230 | 0.77 | LATS1 (0.43) | GSK3BLATS1CDC7MKNK2KDM5B | |
| SCHEMBL4000370 | 0.76 | CDC7 (0.51) | GSK3BLATS1CDC7KDM5BPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081938-A2 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO Ý1,2-A¨PIRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDI NYL-PYRIMIDOÝ1,2,-A¨PYRIMIDIN-6-ONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008056266-A2 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO [1,2-A]PYRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDINYL-PYRIMIDO[1,2-A]PYRIMIDIN-6-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-05-15 | — | — | WO | disclosed |