Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.53 |
| ▸ | JAK3 | P52333 | 7/20 | 0.53 |
| ▸ | JAK1 | P23458 | 6/20 | 0.53 |
| ▸ | BRD4 | O60885 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881588 | 0.85 | JAK1 (0.55) | JAK2JAK3JAK1BRD4HDAC1 | |
| SCHEMBL3968157 | 0.84 | AXL (0.58) | JAK2JAK3JAK1BRD4HDAC1 | |
| SCHEMBL13881452 | 0.83 | JAK2 (0.51) | JAK2JAK3JAK1BRD4HDAC1 | |
| SCHEMBL3969734 | 0.81 | AXL (0.59) | JAK2JAK3JAK1BRD4HDAC1 | |
| SCHEMBL3967636 | 0.81 | AXL (0.55) | JAK2JAK3JAK1BRD4HDAC1 | |
| SCHEMBL4210119 | 0.79 | JAK2 (0.51) | JAK2JAK3JAK1BRD4HDAC1 | |
| SCHEMBL3972528 | 0.78 | SRC (0.58) | JAK2JAK3JAK1BRD4HDAC1 | |
| SCHEMBL3963114 | 0.78 | CDK2 (0.53) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4069202 | 0.78 | AXL (0.52) | JAK2JAK3JAK1BRD4HDAC1 | |
| SCHEMBL3963128 | 0.78 | AXL (0.50) | JAK2JAK3JAK1BRD4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |