Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.51 |
| ▸ | JAK3 | P52333 | 6/20 | 0.51 |
| ▸ | BRD4 | O60885 | 5/20 | 0.51 |
| ▸ | JAK1 | P23458 | 5/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 8/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | YES1 | P07947 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969813 | 0.88 | JAK2 (0.54) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL3965950 | 0.86 | JAK2 (0.51) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL13881557 | 0.85 | AXL (0.60) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL13881584 | 0.84 | AXL (0.56) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL3969938 | 0.83 | AXL (0.56) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL3967251 | 0.82 | JAK2 (0.60) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL3966017 | 0.81 | AXL (0.58) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL13881536 | 0.81 | JAK2 (0.71) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL3964138 | 0.81 | JAK2 (0.59) | JAK2JAK3BRD4JAK1HDAC1 | |
| SCHEMBL3966826 | 0.80 | AXL (0.53) | JAK2JAK3BRD4JAK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |