Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | PDE8A | O60658 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208530 | 0.90 | PDE4A (0.55) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL3952614 | 0.89 | ADORA2A (0.49) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL3959403 | 0.88 | PDE4A (0.47) | YTHDC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3963832 | 0.87 | PDE4A (0.43) | YTHDC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7205445 | 0.86 | PDE4A (0.54) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL3959850 | 0.86 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DPDE8A | |
| SCHEMBL3957510 | 0.86 | YTHDC1 (0.51) | YTHDC1ADORA2AADORA1PDE4APDE4B | |
| SCHEMBL3957656 | 0.86 | ADORA2A (0.52) | YTHDC1ADORA2AADORA1PDE4APDE4B | |
| SCHEMBL4057371 | 0.85 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3956047 | 0.85 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | claimed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |