Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30826701 | 0.88 | PARP1 (0.53) | POLBPARP1LMNATHRBEPHX1 | |
| SCHEMBL13906740 | 0.86 | POLB (0.58) | POLBPARP1LMNATHRBEPHX1 | |
| SCHEMBL4960694 | 0.86 | POLB (0.58) | POLBPARP1LMNATHRBEPHX1 | |
| SCHEMBL1222596 | 0.84 | POLB (0.56) | POLBPARP1LMNATHRBEPHX1 | |
| SCHEMBL13199301 | 0.83 | KDM4E (0.68) | POLBLMNATHRBEPHX1USP30 | |
| SCHEMBL13261261 | 0.81 | STS (0.54) | KDM4EPKMGPR119KMT2A | |
| SCHEMBL21088783 | 0.81 | EPHX1 (0.51) | POLBPARP1LMNATHRBEPHX1 | |
| SCHEMBL69769 | 0.81 | ALDH1A1 (0.58) | EPHX1USP30KDM4EPKMALDH1A1 | |
| SCHEMBL20944523 | 0.81 | MEN1 (0.51) | POLBPARP1LMNATHRBEPHX1 | |
| SCHEMBL26170172 | 0.80 | PARP1 (0.48) | POLBPARP1LMNATHRBEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036035-A1 | BCL-2 INHIBITORS | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |