Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.59 |
| ▸ | JAK3 | P52333 | 7/20 | 0.59 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | CDK9 | P50750 | 3/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.56 |
| ▸ | CCNK | O75909 | 1/20 | 0.56 |
| ▸ | CCND3 | P30281 | 1/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CCNH | P51946 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4079587 | 0.80 | JAK2 (0.54) | JAK2JAK3CDK2CDK9CCNA2 | |
| SCHEMBL3965914 | 0.79 | JAK2 (0.48) | JAK2JAK3CDK2CCNA2TP53 | |
| SCHEMBL29777450 | 0.76 | SYK (0.60) | JAK2JAK3CDK2CDK9CCNA2 | |
| SCHEMBL13881483 | 0.75 | AXL (0.64) | JAK2JAK3CDK9CDK7JAK1 | |
| SCHEMBL13169661 | 0.74 | JAK2 (0.61) | JAK2JAK3CDK2CDK9CCNA2 | |
| SCHEMBL2877419 | 0.74 | JAK2 (0.72) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL30052792 | 0.74 | JAK2 (0.72) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL4378045 | 0.74 | JAK2 (1.00) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL12277255 | 0.74 | PDGFRB (0.69) | JAK3CDK2CDK9CCNA2CCNK | |
| SCHEMBL23704665 | 0.74 | CCNK (0.65) | CDK2CDK9CCNA2CCNKCCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |