Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.54 |
| ▸ | JAK3 | P52333 | 8/20 | 0.54 |
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | CDK9 | P50750 | 3/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971237 | 0.88 | AXL (0.53) | JAK2JAK3CDK2CDK9CCNT1 | |
| SCHEMBL13881457 | 0.83 | JAK2 (0.44) | JAK2JAK3SYKPDGFRBPDGFRA | |
| SCHEMBL3966844 | 0.81 | AXL (0.47) | JAK2JAK3CDK2CDK9CCNT1 | |
| SCHEMBL13881583 | 0.81 | AXL (0.54) | JAK2JAK3CDK1 | |
| SCHEMBL3963688 | 0.80 | JAK2 (0.59) | JAK2JAK3CDK2CDK9CCNT1 | |
| SCHEMBL3969938 | 0.79 | AXL (0.56) | JAK2JAK3CDK9KCNH2JAK1 | |
| SCHEMBL13881451 | 0.79 | AXL (0.53) | JAK2JAK3CDK2CDK9CCNT1 | |
| SCHEMBL3969736 | 0.78 | AURKA (0.37) | JAK2CDK2 | |
| SCHEMBL13881491 | 0.77 | AXL (0.44) | JAK2JAK3JAK1TYK2CDK1 | |
| SCHEMBL3969931 | 0.75 | CCNT1 (0.45) | JAK2JAK3CDK2CDK9CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |