Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967421 | 0.88 | NFKB1 (0.37) | PTGS1PTGS2SMN1; SMN2MAPTTP53 | |
| SCHEMBL3967424 | 0.83 | MAPT (0.42) | POLBSMN1; SMN2MAPTTP53MEN1 | |
| SCHEMBL3967577 | 0.82 | KDM4E (0.40) | CYP2A6POLBSMN1; SMN2MAPTMEN1 | |
| SCHEMBL3965793 | 0.80 | CYP2A6 (0.44) | CYP2A6PTGS2MAPTMEN1ALDH1A1 | |
| SCHEMBL3972542 | 0.80 | INPPL1 (0.38) | ALDH1A1KDM1A | |
| SCHEMBL7253693 | 0.79 | CYP2A6 (0.42) | CYP2A6PDGFRBPDGFRAPTGS1PTGS2 | |
| SCHEMBL2984648 | 0.79 | CYP2A6 (0.42) | CYP2A6PDGFRBPDGFRAPTGS1PTGS2 | |
| SCHEMBL3963157 | 0.79 | KDM4E (0.52) | POLBSMN1; SMN2GAAMEN1ALDH1A1 | |
| SCHEMBL3968687 | 0.75 | ADORA2A (0.50) | SMN1; SMN2MAPTGAAMEN1ALDH1A1 | |
| SCHEMBL26674123 | 0.74 | PTGS1 (0.39) | CYP2A6PDGFRBPDGFRAPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |