Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965260 | 0.90 | BTK (0.46) | BTKEGFRBMXJAK3BDKRB1 | |
| SCHEMBL3961204 | 0.87 | BTK (0.52) | BTKBMXJAK3BDKRB1 | |
| SCHEMBL1322064 | 0.82 | BTK (0.66) | BTKEGFRBMXJAK3 | |
| SCHEMBL3963771 | 0.81 | BTK (0.45) | BTKEGFRBMXJAK3 | |
| SCHEMBL1321960 | 0.80 | BTK (0.58) | BTKEGFRBMXJAK3 | |
| SCHEMBL3957050 | 0.76 | BTK (0.55) | BTKBMXJAK3BDKRB1 | |
| SCHEMBL1322521 | 0.76 | BTK (0.69) | BTKEGFRBMXJAK3 | |
| SCHEMBL1321889 | 0.75 | BTK (0.68) | BTKEGFRBMXJAK3 | |
| SCHEMBL1322842 | 0.74 | BTK (0.54) | BTKEGFRBMXJAK3 | |
| SCHEMBL12120985 | 0.74 | BTK (0.68) | BTKEGFRBMXJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081923-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008033854-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |