⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431181 | 0.87 | — | — | |
| SCHEMBL3429967 | 0.87 | — | — | |
| SCHEMBL1710537 | 0.84 | — | — | |
| SCHEMBL22261436 | 0.72 | — | — | |
| SCHEMBL9297192 | 0.66 | — | — | |
| SCHEMBL8165703 | 0.65 | — | — | |
| SCHEMBL14118306 | 0.60 | — | — | |
| SCHEMBL2330931 | 0.58 | — | — | |
| SCHEMBL818843 | 0.58 | — | — | |
| SCHEMBL1202328 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113717170-A | Estrogen receptor modulators | 里科瑞尔姆IP控股有限责任公司 | 2021-11-30 | — | — | CN | claimed |
| US-20210330651-A1 | ESTROGEN RECEPTOR MODULATORS | RECURIUM IP HOLDINGS, LLC | 2021-10-28 | — | — | US | claimed |
| CN-112745316-A | Estrogen receptor modulators | 里科瑞尔姆IP控股有限责任公司 | 2021-05-04 | — | — | CN | claimed |
| CN-112679495-A | Estrogen receptor modulators | 里科瑞尔姆IP控股有限责任公司 | 2021-04-20 | — | — | CN | claimed |
| EP-3442971-A1 | ESTROGEN RECEPTOR MODULATORS | Zeno Royalties & Milestones, LLC (US) | 2019-02-20 | — | — | EP | claimed |
| CN-109311870-A | estrogen receptor modulators | 芝诺罗耶尔蒂里程碑有限责任公司 | 2019-02-05 | — | — | CN | claimed |
| WO-2017172957-A1 | ESTROGEN RECEPTOR MODULATORS | KALYRA PHARMACEUTICALS, INC. (US) | 2017-10-05 | — | — | WO | claimed |
| CN-103987387-A | Spirothienopyran-piperidine derivatives as ORL-1 receptor antagonists for the treatment of alcohol dependence and abuse | LILLY CO ELI | 2014-08-13 | — | — | CN | claimed |
| CN-101374844-B | Pyrrolopyridazinone compound | UBE INDUSTRIES | 2012-10-24 | — | — | CN | claimed |
| CN-102612520-A | Spiropiperidine compounds as orl-1 receptor antagonists | LILLY CO ELI | 2012-07-25 | — | — | CN | claimed |
| CN-102574860-A | Pyrrolo [2,3-D ] pyrimidine compounds | PFIZER | 2012-07-11 | — | — | CN | claimed |
| CN-1972918-B | Pyrimidine derivatives | HOFFMANN LA ROCHE | 2010-10-13 | — | — | CN | claimed |
| CN-101374844-A | Pyrrolopyridazinone compound | UBE INDUSTRIES (JP) | 2009-02-25 | — | — | CN | claimed |
| CN-101128413-A | Substituted oxyarenes | BAYER CROPSCIENCE AG (DE) | 2008-02-20 | — | — | CN | claimed |
| CN-1972918-A | Pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2007-05-30 | — | — | CN | claimed |
| CN-1290847-C | Aza-aryl piperazines | HOFFMANN LA ROCHE (CH) | 2006-12-20 | — | — | CN | claimed |
| CN-1625558-A | Aza-arylpiperazines | HOFFMANN LA ROCHE (CH) | 2005-06-08 | — | — | CN | claimed |
| CN-1429221-A | 2-phenylpyran-4-one derivatives | ALMIRALL PRODESFARMA SA (CH) | 2003-07-09 | — | — | CN | claimed |
| CN-1133589-A | Novel pyrimidine derivative, herbicide and plant growth regulator | NISSAN CHEMICAL IND LTD (JP) | 1996-10-16 | — | — | CN | claimed |
| EP-4281456-A1 | NOVEL BICYCLIC COMPOUNDS | PRISM BioLab Co., Ltd. (JP) | 2023-11-29 | — | — | EP | disclosed |
| US-20230374034-A1 | NOVEL BICYCLIC COMPOUNDS | Prism BioLab Co., Ltd. (JP) | 2023-11-23 | — | — | US | disclosed |
| WO-2023200017-A1 | NOVEL SEVEN-MEMBERED RING-FUSED COMPOUNDS | Prism BioLab Co., Ltd. (JP) | 2023-10-19 | — | — | WO | disclosed |
| CN-116710455-A | Novel bicyclic compounds | 株式会社棱镜生物实验室 | 2023-09-05 | — | — | CN | disclosed |
| US-20230265104-A1 | NOVEL HETEROCYCLIC COMPOUNDS | Prism BioLab Co., Ltd. (JP) | 2023-08-24 | — | — | US | disclosed |
| EP-4225760-A1 | NOVEL BICYCLIC COMPOUNDS | PRISM BioLab Co., Ltd. (JP) | 2023-08-16 | — | — | EP | disclosed |
| WO-2023140369-A1 | PHOSPHORIC ACID DERIVATIVES | Prism BioLab Co., Ltd. (JP) | 2023-07-27 | — | — | WO | disclosed |
| CN-116348119-A | Novel bicyclic compounds | 株式会社棱镜生物实验室 | 2023-06-27 | — | — | CN | disclosed |
| EP-4182317-A1 | NOVEL HETEROCYCLIC COMPOUNDS | PRISM BioLab Co., Ltd. (JP) | 2023-05-24 | — | — | EP | disclosed |
| CN-116018345-A | Novel heterocyclic compounds | 株式会社棱镜生物实验室 | 2023-04-25 | — | — | CN | disclosed |
| CN-112679495-B | Estrogen receptor modulators | 里科瑞尔姆IP控股有限责任公司 | 2023-03-28 | — | — | CN | disclosed |
| US-20230087941-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC | 2023-03-23 | — | — | US | disclosed |
| US-20230054767-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC | 2023-02-23 | — | — | US | disclosed |
| US-20230053946-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC | 2023-02-23 | — | — | US | disclosed |
| US-20230042653-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC | 2023-02-09 | — | — | US | disclosed |
| CN-115103673-A | Combination (I) | 里科瑞尔姆IP控股有限责任公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-115038450-A | Combination of | 里科瑞尔姆IP控股有限责任公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-115023228-A | Combination of | 里科瑞尔姆IP控股有限责任公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-115023224-A | Combination of | 里科瑞尔姆IP控股有限责任公司 | 2022-09-06 | — | — | CN | disclosed |
| WO-2022075486-A1 | NOVEL BICYCLIC COMPOUNDS | Prism BioLab Co., Ltd. (JP) | 2022-04-14 | — | — | WO | disclosed |
| WO-2022014724-A1 | NOVEL HETEROCYCLIC COMPOUNDS | Prism BioLab Co., Ltd. (JP) | 2022-01-20 | — | — | WO | disclosed |
| CN-113717170-A | Estrogen receptor modulators | 里科瑞尔姆IP控股有限责任公司 | 2021-11-30 | — | — | CN | disclosed |
| US-20210330651-A1 | ESTROGEN RECEPTOR MODULATORS | RECURIUM IP HOLDINGS, LLC | 2021-10-28 | — | — | US | disclosed |
| CN-109311870-B | Estrogen receptor modulators | 里科瑞尔姆IP控股有限责任公司 | 2021-09-21 | — | — | CN | disclosed |
| US-11065234-B2 | Estrogen receptor modulators | RECURIUM IP HOLDINGS, LLC (US) | 2021-07-20 | — | — | US | disclosed |
| US-11065233-B2 | Estrogen receptor modulators | RECURIUM IP HOLDINGS, LLC (US) | 2021-07-20 | — | — | US | disclosed |
| WO-2021127042-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127046-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127036-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127043-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127047-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC (US) | 2021-06-24 | — | — | WO | disclosed |
| CN-112745316-A | Estrogen receptor modulators | 里科瑞尔姆IP控股有限责任公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-112679495-A | Estrogen receptor modulators | 里科瑞尔姆IP控股有限责任公司 | 2021-04-20 | — | — | CN | disclosed |
| US-10959989-B2 | Estrogen receptor modulators | RECURIUM IP HOLDINGS, LLC (US) | 2021-03-30 | — | — | US | disclosed |
| US-20200261429-A1 | ESTROGEN RECEPTOR MODULATORS | KALYRA PHARMACEUTICALS, INC. | 2020-08-20 | — | — | US | disclosed |
| US-20200261430-A1 | ESTROGEN RECEPTOR MODULATORS | KALYRA PHARMACEUTICALS, INC. | 2020-08-20 | — | — | US | disclosed |
| US-20200261428-A1 | ESTROGEN RECEPTOR MODULATORS | KALYRA PHARMACEUTICALS, INC. | 2020-08-20 | — | — | US | disclosed |
| US-20190142811-A1 | ESTROGEN RECEPTOR MODULATORS | RECURIUM IP HOLDINGS, LLC | 2019-05-16 | — | — | US | disclosed |
| EP-3442971-A1 | ESTROGEN RECEPTOR MODULATORS | Zeno Royalties & Milestones, LLC (US) | 2019-02-20 | — | — | EP | disclosed |
| CN-109311870-A | estrogen receptor modulators | 芝诺罗耶尔蒂里程碑有限责任公司 | 2019-02-05 | — | — | CN | disclosed |
| WO-2017172957-A1 | ESTROGEN RECEPTOR MODULATORS | KALYRA PHARMACEUTICALS, INC. (US) | 2017-10-05 | — | — | WO | disclosed |
| CN-102212062-B | Derivative of amino ester, salt thereof and using method | GUANGDONG HEC PHARMACEUTICAL | 2015-04-29 | — | — | CN | disclosed |
| CN-103987387-A | Spirothienopyran-piperidine derivatives as ORL-1 receptor antagonists for the treatment of alcohol dependence and abuse | LILLY CO ELI | 2014-08-13 | — | — | CN | disclosed |
| CN-103958478-A | Novel bicyclic dihydroisoquinolin-1-one derivatives | HOFFMANN LA ROCHE | 2014-07-30 | — | — | CN | disclosed |
| CN-103906735-A | Novel aryl-quinoline derivatives | HOFFMANN LA ROCHE | 2014-07-02 | — | — | CN | disclosed |
| CN-103827101-A | New bicyclic dihydroquinoline-2-one derivatives | HOFFMANN LA ROCHE | 2014-05-28 | — | — | CN | disclosed |
| CN-103814021-A | New dihydroquinoline-2-one derivatives | HOFFMANN LA ROCHE | 2014-05-21 | — | — | CN | disclosed |
| CN-103328436-A | Novel aryl-benzocycloalkylamide derivatives | HOFFMANN LA ROCHE | 2013-09-25 | — | — | CN | disclosed |
| CN-103249727-A | New biaryl amide derivatives | HOFFMANN LA ROCHE | 2013-08-14 | — | — | CN | disclosed |
| CN-103068826-A | New azacyclic compounds | HOFFMANN LA ROCHE | 2013-04-24 | — | — | CN | disclosed |
| CN-102971302-A | 6-acyl-1, 2, 4-triazine-3, 5-dione derivatives and herbicides | KUMIAI CHEMICAL INDUSTRY CO | 2013-03-13 | — | — | CN | disclosed |
| CN-102858743-A | Spiro-condensed cyclohexane derivatives as HSL inhibitors useful for the treatment of diabetes | HOFFMANN LA ROCHE | 2013-01-02 | — | — | CN | disclosed |
| CN-101374844-B | Pyrrolopyridazinone compound | UBE INDUSTRIES | 2012-10-24 | — | — | CN | disclosed |
| CN-102612520-A | Spiropiperidine compounds as orl-1 receptor antagonists | LILLY CO ELI | 2012-07-25 | — | — | CN | disclosed |
| CN-102574860-A | Pyrrolo [2,3-D ] pyrimidine compounds | PFIZER | 2012-07-11 | — | — | CN | disclosed |
| CN-102459159-A | Alkanoylamino benzamide aniline hdac inihibitor compounds | GILEAD COLORADO INC | 2012-05-16 | — | — | CN | disclosed |
| CN-1972918-B | Pyrimidine derivatives | HOFFMANN LA ROCHE | 2010-10-13 | — | — | CN | disclosed |
| CN-101778832-A | Oxopyrazine derivative and weedicide | KUMIAI CHEMICAL INDUSTRY CO | 2010-07-14 | — | — | CN | disclosed |
| EP-2081918-A2 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| CN-101374844-A | Pyrrolopyridazinone compound | UBE INDUSTRIES (JP) | 2009-02-25 | — | — | CN | disclosed |
| US-20080255121-A1 | Combination Drug for Treating Autoimmune Disease | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2008-10-16 | — | — | US | disclosed |
| CN-101230060-A | Substitutional piperidines | SPEEDEL EXPERIMENTA AG (CH) | 2008-07-30 | — | — | CN | disclosed |
| WO-2008042928-A2 | OXADIAZOLE AND THIADIAZOLE DERIVATIVES AS MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2008-04-10 | — | — | WO | disclosed |
| CN-101151262-A | Substituted piperidines | SPEEDEL EXPERIMENTA AG (CH) | 2008-03-26 | — | — | CN | disclosed |
| CN-101151247-A | 3,4, 5-substituted piperidines as renin inhibitors | SPEEDEL EXPERIMENTA AG (CH) | 2008-03-26 | — | — | CN | disclosed |
| CN-101128413-A | Substituted oxyarenes | BAYER CROPSCIENCE AG (DE) | 2008-02-20 | — | — | CN | disclosed |
| EP-1815867-A1 | COMBINATION DRUG FOR TREATING AUTOIMMUNE DISEASE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2007-08-08 | — | — | EP | disclosed |
| CN-1976932-A | Fused quinoline derivative and use thereof | TAKEDA PHARMACEUTICAL (JP) | 2007-06-06 | — | — | CN | disclosed |
| CN-1972918-A | Pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2007-05-30 | — | — | CN | disclosed |
| CN-1290847-C | Aza-aryl piperazines | HOFFMANN LA ROCHE (CH) | 2006-12-20 | — | — | CN | disclosed |
| CN-1642954-A | Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2005-07-20 | — | — | CN | disclosed |
| CN-1625558-A | Aza-arylpiperazines | HOFFMANN LA ROCHE (CH) | 2005-06-08 | — | — | CN | disclosed |
| CN-1202095-C | Heteroaromatic ring compounds | SUMITOMO PHARMA (JP) | 2005-05-18 | — | — | CN | disclosed |
| CN-1138764-C | Isoxazole derivatives | ס����ҩ��ʽ���� | 2004-02-18 | — | — | CN | disclosed |
| CN-1464878-A | Tricyclic 2-pyridone compounds useful as hiv reverse transcriptase inhibitors | PONT PHARM CO DU (US) | 2003-12-31 | — | — | CN | disclosed |
| CN-1130351-C | 1,5-benzodiazepine derivatives | ZERIA PHARM CO LTD (JP) | 2003-12-10 | — | — | CN | disclosed |
| CN-1429221-A | 2-phenylpyran-4-one derivatives | ALMIRALL PRODESFARMA SA (CH) | 2003-07-09 | — | — | CN | disclosed |
| US-6576765-B2 | Process for preparing amic acid esters | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| US-20030032667-A1 | PROCESS FOR PREPARING AMIC ACID ESTERS | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2003-02-13 | — | — | US | disclosed |
| CN-1361770-A | Heteroaromatic ring compounds | SUMITOMO PHARMA (JP) | 2002-07-31 | — | — | CN | disclosed |
| CN-1361783-A | Thiazoloderivatives and pharmaceutical compositions containing them | KNOLL AG (DE) | 2002-07-31 | — | — | CN | disclosed |
| EP-1182199-A1 | PROCESS FOR PREPARING AMIC ACID ESTERS | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2002-02-27 | — | — | EP | disclosed |
| CN-1058964-C | Branched-amino-sbustituted thiazoles, processes for their preparation and the pharmaceutical compositions which contain them | SANOFI SA (FR) | 2000-11-29 | — | — | CN | disclosed |
| CN-1057674-C | Growth promoting composition and production thereof | KITASATO INST (JP) | 2000-10-25 | — | — | CN | disclosed |
| CN-1252794-A | Isoxazole derivatives | SUMITOMO PHARMA (JP) | 2000-05-10 | — | — | CN | disclosed |
| CN-1246850-A | 1,5-benzodiazepine derivatives | ZERIA PHARM CO LTD (JP) | 2000-03-08 | — | — | CN | disclosed |
| EP-0659747-B1 | Branched aminothiazole derivatives process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-04-01 | — | — | EP | disclosed |
| CN-1169986-A | 2.9-diamino-and 2-amino-8-carbamoyl-4-hydroxy-aldanoic acid amide derivatives | CIBA GEIGY AG (CH) | 1998-01-14 | — | — | CN | disclosed |
| CN-1161034-A | Substituted cycloalkylamino and cycloalkoxy heterocycles, process for preparing the same and their use as pesticides | HOECHST SCHERING AGREVO GMBH (DE) | 1997-10-01 | — | — | CN | disclosed |
| CN-1133589-A | Novel pyrimidine derivative, herbicide and plant growth regulator | NISSAN CHEMICAL IND LTD (JP) | 1996-10-16 | — | — | CN | disclosed |
| EP-0659747-A1 | Branched aminothiazole derivatives process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-06-28 | — | — | EP | disclosed |
| CN-1025565-C | preparation method of digestive tract contraction movement stimulant | KITASATO INST (JP) | 1994-08-03 | — | — | CN | disclosed |
| CN-1071433-A | The method for preparing digestive tract contractile motion stimulant | KITASATO INST (JP) | 1993-04-28 | — | — | CN | disclosed |
| CN-88101027-A | Growth promoting composition and preparation method thereof | — | 1988-08-31 | — | — | CN | disclosed |
| CN-86106828-A | DIGESTIVE TRACT CONTRACTILE MOTION STIMULANT | — | 1987-04-08 | — | — | CN | disclosed |
| CN-86106828-A | DIGESTIVE TRACT CONTRACTILE MOTION STIMULANT | — | 1987-04-08 | — | — | CN | disclosed |