Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19291655 | 0.87 | DHFR (0.43) | DHFRHSD11B1KDM4CKMT2AMEN1 | |
| SCHEMBL16149995 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2 | |
| SCHEMBL2205030 | 0.81 | DHFR (0.45) | DHFRHSD11B1 | |
| SCHEMBL13779680 | 0.78 | DHFR (0.44) | DHFRHSD11B1KDM4CSLC6A3 | |
| SCHEMBL3184997 | 0.77 | DHFR (0.53) | DHFRHSD11B1KDM4CKMT2AMEN1 | |
| SCHEMBL5726536 | 0.77 | DHFR (0.39) | DHFRHSD11B1KDM4CKMT2AMEN1 | |
| SCHEMBL10183535 | 0.77 | DHFR (0.45) | DHFRHSD11B1KDM4CSLC6A3POLB | |
| SCHEMBL3189000 | 0.76 | DHFR (0.55) | DHFRHSD11B1KDM4CKMT2AMEN1 | |
| SCHEMBL10697204 | 0.76 | DHFR (0.41) | DHFRHSD11B1KDM4C | |
| SCHEMBL29646513 | 0.76 | DHFR (0.57) | DHFRHSD11B1KDM4CKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |