Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17672370 | 0.91 | ATM (0.34) | ATM | |
| SCHEMBL29965898 | 0.88 | SMN1; SMN2 (0.33) | BCHE | |
| SCHEMBL10205147 | 0.84 | BCHE (0.49) | BCHEATMKDM4EALDH1A1MEN1 | |
| SCHEMBL3709106 | 0.84 | ATM (0.42) | ATM | |
| SCHEMBL15448158 | 0.81 | SMN1; SMN2 (0.35) | ATMMAPTLMNA | |
| SCHEMBL12023144 | 0.80 | SMN1; SMN2 (0.42) | BCHEKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL25405239 | 0.78 | ALDH1A1 (0.46) | BCHEKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9912673 | 0.78 | BCHE (0.38) | BCHEKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL25401470 | 0.78 | ALDH1A1 (0.46) | BCHEKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19798957 | 0.78 | BCHE (0.35) | BCHEKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081927-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2008036216-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |