Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.46 |
| ▸ | CALCA | P06881 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL969545 | 0.91 | CALCA (0.41) | EGLN1CALCATP53L3MBTL1THRB | |
| SCHEMBL966194 | 0.90 | CALCA (0.42) | CALCATP53L3MBTL1THRBMAPT | |
| SCHEMBL968296 | 0.89 | CALCA (0.41) | CALCATP53L3MBTL1THRBMAPT | |
| SCHEMBL966267 | 0.88 | TP53 (0.42) | CALCATP53L3MBTL1THRBMAPT | |
| SCHEMBL968739 | 0.88 | CALCA (0.41) | CALCATP53L3MBTL1THRBMAPT | |
| SCHEMBL968731 | 0.87 | CALCA (0.41) | CALCATP53L3MBTL1THRBMAPT | |
| SCHEMBL965385 | 0.86 | CALCA (0.39) | CALCATP53L3MBTL1THRBMAPT | |
| SCHEMBL969973 | 0.86 | NPSR1 (0.42) | CALCATP53L3MBTL1THRBMAPT | |
| SCHEMBL967580 | 0.86 | ADORA2A (0.42) | CALCATP53L3MBTL1THRBMAPT | |
| SCHEMBL968666 | 0.85 | RPS6KB1 (0.41) | CALCATP53L3MBTL1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622615-A4 | NAPHTHYRIDINE INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-02-18 | — | — | EP | claimed |
| EP-1622615-A2 | NAPHTHYRIDINE INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-08 | — | — | EP | claimed |
| WO-2004101512-A2 | NAPHTHYRIDINE INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-11-25 | — | — | WO | claimed |