Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.40 |
| ▸ | AXL | P30530 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 13/20 | 0.38 |
| ▸ | FLT3 | P36888 | 10/20 | 0.38 |
| ▸ | MERTK | Q12866 | 10/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 8/20 | 0.38 |
| ▸ | SELP | P16109 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958625 | 0.93 | FGFR1 (0.38) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL3966411 | 0.92 | TYRO3 (0.39) | FGFR1AXLEGFRFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3965773 | 0.92 | FGFR1 (0.39) | FGFR1AXLEGFRFGFR2FGFR4 | |
| SCHEMBL3961602 | 0.91 | FGFR1 (0.42) | FGFR1AXLEGFRFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3969445 | 0.90 | FGFR1 (0.42) | FGFR1AXLEGFRFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3964263 | 0.90 | FGFR1 (0.42) | FGFR1AXLEGFRFGFR2FGFR4 | |
| SCHEMBL4073584 | 0.89 | FGFR1 (0.49) | FGFR1AXLEGFRFGFR2FGFR4 | |
| SCHEMBL3962136 | 0.89 | FGFR1 (0.40) | FGFR1AXLEGFRFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL4084184 | 0.89 | FGFR1 (0.49) | FGFR1AXLEGFRFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3961798 | 0.89 | FGFR1 (0.49) | FGFR1AXLEGFRFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |