Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 13/20 | 0.39 |
| ▸ | MERTK | Q12866 | 13/20 | 0.39 |
| ▸ | FLT3 | P36888 | 12/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 10/20 | 0.39 |
| ▸ | AXL | P30530 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963760 | 0.93 | ICAM1 (0.36) | TYRO3MERTKFLT3GAS6EGFR | |
| SCHEMBL3963752 | 0.93 | ICAM1 (0.36) | TYRO3MERTKFLT3GAS6EGFR | |
| SCHEMBL3964622 | 0.92 | FGFR1 (0.40) | TYRO3MERTKFLT3GAS6AXL | |
| Hydrochloric Acid SCHEMBL3965328 | 0.89 | FLT3 (0.38) | TYRO3MERTKFLT3GAS6AXL | |
| SCHEMBL3964769 | 0.89 | FGFR1 (0.45) | TYRO3MERTKFLT3GAS6AXL | |
| Hydrochloric Acid SCHEMBL3965367 | 0.88 | FGFR1 (0.45) | TYRO3MERTKFLT3GAS6AXL | |
| Hydrochloric Acid SCHEMBL3958567 | 0.88 | FGFR1 (0.45) | TYRO3MERTKFLT3GAS6AXL | |
| SCHEMBL3964338 | 0.88 | TYRO3 (0.43) | TYRO3MERTKFLT3GAS6AXL | |
| SCHEMBL13768446 | 0.87 | FLT3 (0.41) | TYRO3MERTKFLT3GAS6AXL | |
| Hydrochloric Acid SCHEMBL3969434 | 0.87 | FLT3 (0.40) | TYRO3MERTKFLT3GAS6AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |