Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 8/20 | 0.44 |
| ▸ | CNR1 | P21554 | 5/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966675 | 1.00 | KDM4E (0.67) | KDM4ESMN1; SMN2CYP1A2LMNACNR2 | |
| SCHEMBL7329638 | 0.91 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2LMNACNR2 | |
| SCHEMBL11257190 | 0.87 | KDM4E (0.53) | KDM4ESMN1; SMN2CYP1A2LMNACNR2 | |
| SCHEMBL11741159 | 0.84 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2LMNACNR2 | |
| SCHEMBL4129093 | 0.83 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2LMNACNR2 | |
| SCHEMBL4129090 | 0.83 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2LMNACNR2 | |
| SCHEMBL11750696 | 0.81 | KDM4E (0.76) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| Flumequine SCHEMBL49830 | 0.80 | KDM4E (1.00) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL11748080 | 0.80 | KDM4E (0.74) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL11751414 | 0.80 | KDM4E (0.74) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175217-B8 | (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS | WOCKHARDT LTD (IN) | 2009-03-18 | — | — | EP | claimed |
| EP-1175217-A2 | (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS | Wockhardt Limited (IN) | 2002-01-30 | — | — | EP | claimed |
| WO-2000068229-A2 | (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS | WOCKHARDT LIMITED (IN) | 2000-11-16 | — | — | WO | claimed |
| EP-1309383-B1 | COMPOSITIONS FOR DEFOAMING AQUEOUS COMPOSITIONS | COGNIS IP MAN GMBH (DE) | 2009-03-18 | — | — | EP | disclosed |
| EP-1175217-B8 | (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS | WOCKHARDT LTD (IN) | 2009-03-18 | — | — | EP | disclosed |
| US-6512016-B2 | Organosilicone compound which has defoaming activity in aqueous based compositions and reaction product of linking agent and polyether; latex paints | COGNIS CORPORATION | 2003-01-28 | — | — | US | disclosed |
| EP-1175217-A2 | (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS | Wockhardt Limited (IN) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000068229-A2 | (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS | WOCKHARDT LIMITED (IN) | 2000-11-16 | — | — | WO | disclosed |