Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966675 | 0.91 | KDM4E (0.67) | KDM4ESMN1; SMN2CYP1A2CNR1LMNA | |
| SCHEMBL3965154 | 0.91 | KDM4E (0.67) | KDM4ESMN1; SMN2CYP1A2CNR1LMNA | |
| SCHEMBL6334232 | 0.83 | KDM4E (0.44) | KDM4ESMN1; SMN2CYP1A2CNR1LMNA | |
| SCHEMBL3520185 | 0.80 | CNR1 (0.64) | KDM4ECNR1ALDH1A1GAAHPGD | |
| SCHEMBL4129090 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2CNR1LMNA | |
| SCHEMBL4129093 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2CNR1LMNA | |
| SCHEMBL11257190 | 0.77 | KDM4E (0.53) | KDM4ESMN1; SMN2CYP1A2CNR1LMNA | |
| SCHEMBL11741159 | 0.75 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2CNR1LMNA | |
| SCHEMBL11745247 | 0.74 | KDM4E (0.56) | KDM4ESMN1; SMN2CYP1A2CNR1LMNA | |
| SCHEMBL11750696 | 0.74 | KDM4E (0.76) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102901-A | 5-hydroxytrypamine receptor antaonists | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-04-07 | — | — | US | disclosed |
| EP-0393766-A2 | New 3-N substituted carbamoyl-indole derivatives | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-10-24 | — | — | EP | disclosed |