Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.42 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377181 | 0.72 | CHRNA7 (0.55) | GPR119ITGB3ITGA2BCHRNA7CHRNA10 | |
| SCHEMBL2387391 | 0.70 | GFER (0.62) | MAPTMEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL4989513 | 0.69 | CHRNA7 (0.58) | CHRNA7CHRNA10CHRNA9MAPTKMT2A | |
| SCHEMBL14924440 | 0.69 | HTT (0.57) | MAPTMEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL20387730 | 0.67 | MAPT (0.64) | MAPTMEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL6779212 | 0.67 | MAPT (0.63) | CHRNA7CHRNA10CHRNA9MAPTMEN1 | |
| SCHEMBL11919049 | 0.67 | MAPT (0.53) | MAPTMEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL16130769 | 0.66 | USP2 (0.73) | GPR119CHRNA7CHRNA10CHRNA9HRH3 | |
| SCHEMBL5321968 | 0.66 | CHRNA7 (0.51) | GPR119CHRNA7CHRNA10CHRNA9HRH3 | |
| SCHEMBL2558142 | 0.66 | MEN1 (0.50) | MAPTMEN1HPGDKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807407-B1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-29 | — | — | EP | claimed |