Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.51 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 4/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1483601 | 0.86 | MAPT (0.63) | ALDH1A1MAPTKMT2ALMNAMEN1 | |
| SCHEMBL6150875 | 0.84 | GFER (0.68) | SYKCASP6GFERALDH1A1MAPT | |
| SCHEMBL1811256 | 0.84 | GFER (0.68) | SYKCASP6GFERALDH1A1MAPT | |
| SCHEMBL4985313 | 0.82 | GFER (0.70) | CHRNA7CHRNA10CHRNA9SYKCHEK1 | |
| SCHEMBL22542064 | 0.82 | AKR1C3 (0.59) | CASP6GFERALDH1A1MAPTKMT2A | |
| SCHEMBL4990421 | 0.81 | NAMPT (0.52) | CHRNA7CHRNA10CHRNA9CHEK1CASP6 | |
| SCHEMBL30508269 | 0.81 | AKR1C3 (0.58) | CASP6GFERALDH1A1MAPTKMT2A | |
| SCHEMBL11048879 | 0.80 | HRH3 (0.59) | ALDH1A1MAPTKMT2ALMNAHRH3 | |
| SCHEMBL20883570 | 0.79 | PANK3 (0.56) | CASP6GFERALDH1A1MAPTKMT2A | |
| SCHEMBL7258616 | 0.79 | CASP6 (0.53) | CHRNA7CHRNA10CHRNA9CHEK1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007097697-A1 | THERAPEUTIC QUINOLINE COMPOUNDS THAT ARE 5HT1B MODULATORS | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | WO | claimed |
| WO-2007097697-A1 | THERAPEUTIC QUINOLINE COMPOUNDS THAT ARE 5HT1B MODULATORS | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | WO | disclosed |