Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 11/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3960771 | 0.90 | KMT2A (0.53) | KMT2ANR3C1PGRNR3C2AR | |
| SCHEMBL3970562 | 0.85 | KMT2A (0.50) | KMT2ANR3C1PGRNR3C2AR | |
| SCHEMBL3966943 | 0.85 | KMT2A (0.50) | KMT2ANR3C1PGRNR3C2AR | |
| SCHEMBL3969322 | 0.83 | KMT2A (0.48) | KMT2ANR3C1PGRNR3C2AR | |
| SCHEMBL3970830 | 0.79 | NR3C1 (0.62) | KMT2ANR3C1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL3959774 | 0.79 | NR3C1 (0.52) | KMT2ANR3C1PGRNR3C2AR | |
| SCHEMBL3971896 | 0.79 | NR3C1 (0.52) | KMT2ANR3C1PGRNR3C2AR | |
| SCHEMBL3968196 | 0.78 | NR3C1 (0.63) | KMT2ANR3C1PGRNR3C2AR | |
| SCHEMBL3965644 | 0.77 | NR3C1 (0.49) | KMT2ANR3C1PGRNR3C2AR | |
| SCHEMBL3966910 | 0.76 | NR3C1 (0.51) | KMT2ANR3C1PGRNR3C2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363876-B1 | GLUCOCORTICOID RECEPTOR MODULATORS | KAROBIO AB (SE) | 2009-07-29 | — | — | EP | disclosed |
| EP-1363876-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | Abbott Laboratories (US) | 2003-11-26 | — | — | EP | disclosed |
| US-6583180-B2 | Antidiabetic agents | ABBOTT LABORATORIES | 2003-06-24 | — | — | US | disclosed |
| WO-2002064550-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | ABBOTT LABORATORIES (US) | 2002-08-22 | — | — | WO | disclosed |