Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 10/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | TEK | Q02763 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | YES1 | P07947 | 2/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.55 |
| ▸ | CSK | P41240 | 2/20 | 0.55 |
| ▸ | BLK | P51451 | 2/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969809 | 0.92 | AXL (0.55) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL13881557 | 0.91 | AXL (0.60) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL3971111 | 0.90 | AXL (0.55) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL3968117 | 0.90 | AXL (0.62) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL13881537 | 0.88 | AXL (0.60) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL4083891 | 0.88 | AXL (0.55) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL4078667 | 0.88 | AXL (0.55) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL13881535 | 0.87 | AXL (0.59) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL13881483 | 0.87 | AXL (0.64) | AXLSRCPDGFRBLCKFGFR1 | |
| SCHEMBL3973039 | 0.87 | SRC (0.58) | AXLSRCPDGFRBLCKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |