Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.55 |
| ▸ | JAK3 | P52333 | 8/20 | 0.51 |
| ▸ | JAK2 | O60674 | 7/20 | 0.51 |
| ▸ | JAK1 | P23458 | 6/20 | 0.51 |
| ▸ | BRD4 | O60885 | 5/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | TYK2 | P29597 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 7/20 | 0.45 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | TEK | Q02763 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966017 | 0.88 | AXL (0.58) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL3968117 | 0.86 | AXL (0.62) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL4078667 | 0.86 | AXL (0.55) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL3973039 | 0.86 | SRC (0.58) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL3969809 | 0.85 | AXL (0.55) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL13881537 | 0.85 | AXL (0.60) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL3971086 | 0.84 | AXL (0.56) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL13881557 | 0.84 | AXL (0.60) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL13881535 | 0.84 | AXL (0.59) | AXLJAK3JAK2JAK1BRD4 | |
| SCHEMBL13881483 | 0.84 | AXL (0.64) | AXLJAK3JAK2JAK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |