SCHEMBL3966039 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	JAK2	O60674	4/20	0.39

▸	BRD4	O60885	1/20	0.39

▸	TTK	P33981	1/20	0.39

▸	EGFR	P00533	4/20	0.39

▸	JAK3	P52333	3/20	0.39

▸	JAK1	P23458	2/20	0.39

▸	BTK	Q06187	2/20	0.39

▸	KCNH2	Q12809	1/20	0.39

▸	CDK2	P24941	9/20	0.38

▸	AURKA	O14965	2/20	0.38

▸	PDPK1	O15530	1/20	0.37

▸	CCNA2	P20248	7/20	0.37

▸	CCNT1	O60563	6/20	0.37

▸	CDK9	P50750	6/20	0.37

▸	PTK2	Q05397	3/20	0.37

▸	CCNA1	P78396	1/20	0.37

▸	CDK1	P06493	2/20	0.36

▸	CCNB1	P14635	2/20	0.36

▸	CDK7	P50613	2/20	0.36

▸	CCNH	P51946	2/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3975618	0.88	TSHR (0.40)	JAK2BRD4TTKEGFRJAK3
SCHEMBL3971546	0.88	CDK2 (0.45)	JAK2BRD4TTKEGFRJAK3
SCHEMBL3964197	0.87	JAK2 (0.40)	JAK2BRD4TTKEGFRJAK3
SCHEMBL13883690	0.86	JAK2 (0.43)	JAK2BRD4TTKEGFRJAK3
SCHEMBL4084023	0.86	TTK (0.49)	JAK2BRD4TTKEGFRJAK3
SCHEMBL13883500	0.86	JAK2 (0.46)	JAK2BRD4TTKEGFRJAK3
SCHEMBL4072936	0.85	TTK (0.42)	JAK2BRD4TTKEGFRJAK3
SCHEMBL13883687	0.85	KDR (0.44)	JAK2BRD4TTKEGFRJAK3
SCHEMBL13883495	0.85	TTK (0.42)	JAK2BRD4TTKEGFRJAK3
SCHEMBL13883685	0.84	JAK2 (0.44)	JAK2BRD4TTKEGFRJAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009049028-A1	PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS	TARGEGEN INC. (US)	2009-04-16	—	—	WO	disclosed