Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205318 | 0.92 | PPARA (0.39) | PPARAPPARGCYP4F2CYP4A11TAAR1 | |
| SCHEMBL29818836 | 0.81 | TAAR1 (0.45) | PPARAPPARGCYP4F2CYP4A11TAAR1 | |
| SCHEMBL2206389 | 0.81 | TAAR1 (0.45) | PPARAPPARGCYP4F2CYP4A11TAAR1 | |
| SCHEMBL4568766 | 0.81 | PPARA (0.53) | PPARAPPARGGGPS1CYP2D6 | |
| SCHEMBL20332003 | 0.79 | TAAR1 (0.42) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL15151060 | 0.79 | TAAR1 (0.39) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL15150987 | 0.79 | TAAR1 (0.39) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL15150976 | 0.79 | TAAR1 (0.39) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL4568995 | 0.78 | VDR (0.38) | PPARAPPARGTAAR1MAPK1L3MBTL1 | |
| SCHEMBL4568988 | 0.78 | VDR (0.38) | PPARAPPARGTAAR1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |