Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Ethacridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.96 |
| ▸ | CASP7 | P55210 | 3/20 | 0.96 |
| ▸ | CASP1 | P29466 | 2/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.96 |
| ▸ | HPGD | P15428 | 2/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.96 |
| ▸ | MAPT | P10636 | 1/20 | 0.96 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.96 |
| ▸ | BLM | P54132 | 2/20 | 0.76 |
| ▸ | TERT | O14746 | 1/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | THRB | P10828 | 1/20 | 0.76 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethacridine SCHEMBL30006678 | 0.98 | MEN1 (1.00) | MEN1KMT2ACASP7CASP1KDM4E | |
| Ethacridine SCHEMBL30775016 | 0.98 | MEN1 (1.00) | MEN1KMT2ACASP7CASP1KDM4E | |
| Ethacridine SCHEMBL31197660 | 0.98 | MEN1 (1.00) | MEN1KMT2ACASP7CASP1KDM4E | |
| Ethacridine SCHEMBL138154 | 0.98 | MEN1 (1.00) | MEN1KMT2ACASP7CASP1KDM4E | |
| Ethacridine SCHEMBL29355684 | 0.97 | MEN1 (0.98) | MEN1KMT2ACASP7CASP1KDM4E | |
| Ethacridine SCHEMBL1649444 | 0.97 | MEN1 (0.98) | MEN1KMT2ACASP7CASP1KDM4E | |
| Ethacridine SCHEMBL8676831 | 0.97 | MEN1 (0.98) | MEN1KMT2ACASP7CASP1KDM4E | |
| Ethacridine SCHEMBL29568982 | 0.97 | MEN1 (0.98) | MEN1KMT2ACASP7CASP1KDM4E | |
| Lactic Acid SCHEMBL8375854 | 0.93 | MEN1 (0.91) | MEN1KMT2ACASP7CASP1KDM4E | |
| Ethacridine SCHEMBL11662539 | 0.87 | MEN1 (1.00) | MEN1KMT2ACASP7CASP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719522-B1 | Medicinal composition comprising TCF-II | DAIICHI SANKYO CO LTD (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1719522-A1 | Medicinal composition comprising TCF-II | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-11-08 | — | — | EP | disclosed |
| EP-0821969-A2 | Medicinal Composition comprising TCF-II | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-02-04 | — | — | EP | disclosed |