Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964127 | 0.91 | FGFR1 (0.44) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL3965524 | 0.91 | SLC2A1 (0.42) | DRD2HTR2AHTR7HTR6SLC6A2 | |
| Hydrochloric Acid SCHEMBL3964469 | 0.88 | MERTK (0.36) | DRD2HTR2AHTR7HTR6SLC6A2 | |
| Hydrochloric Acid SCHEMBL3965201 | 0.85 | SLC2A1 (0.38) | IKBKBCHUKIKBKGCD274FGFR1 | |
| Hydrochloric Acid SCHEMBL3970371 | 0.82 | CA1 (0.40) | DRD2SLC6A2SLC6A4IKBKBCHUK | |
| Hydrochloric Acid SCHEMBL3967678 | 0.82 | TACR2 (0.38) | DRD2HTR2AHTR7HTR6 | |
| SCHEMBL3963837 | 0.81 | FGFR1 (0.44) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL2983692 | 0.81 | PRKCQ (0.37) | IKBKBCHUKIKBKGCD274ADORA1 | |
| SCHEMBL3971053 | 0.80 | SLC2A1 (0.43) | DRD2HTR2AHTR7HTR6FGFR1 | |
| SCHEMBL3966578 | 0.80 | FGFR1 (0.50) | FGFR1EGFRSRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |