Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969743 | 0.93 | AXL (0.42) | AXLAURKBJAK2JAK3JAK1 | |
| SCHEMBL3971087 | 0.90 | AXL (0.41) | AXLAURKBJAK2JAK3JAK1 | |
| SCHEMBL3965200 | 0.88 | AXL (0.41) | AXLJAK2JAK3JAK1TYK2 | |
| SCHEMBL3967985 | 0.88 | AXL (0.39) | AXLAURKBJAK2JAK3JAK1 | |
| SCHEMBL3967639 | 0.87 | AXL (0.39) | AXLAURKBJAK2JAK3JAK1 | |
| SCHEMBL3966066 | 0.87 | AXL (0.41) | AXLAURKBJAK2JAK3JAK1 | |
| SCHEMBL3967352 | 0.87 | CHEK1 (0.39) | AXLAURKBJAK2JAK3JAK1 | |
| SCHEMBL3965488 | 0.87 | CHRNA1 (0.41) | AXLAURKBJAK2JAK3JAK1 | |
| SCHEMBL3971221 | 0.87 | JAK2 (0.41) | AXLAURKBJAK2JAK3JAK1 | |
| SCHEMBL3964140 | 0.85 | SRC (0.41) | AXLJAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |