Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 8/20 | 0.40 |
| ▸ | JAK3 | P52333 | 7/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRND | Q07001 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 2/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969743 | 0.91 | AXL (0.42) | AXLJAK2JAK3LTA4HCHRNA1 | |
| SCHEMBL3965488 | 0.91 | CHRNA1 (0.41) | AXLJAK2JAK3LTA4HCHRNA1 | |
| SCHEMBL3971087 | 0.89 | AXL (0.41) | AXLJAK2JAK3LTA4HCHRNA1 | |
| SCHEMBL3968635 | 0.89 | AXL (0.39) | AXLJAK2JAK3YES1EPHB4 | |
| SCHEMBL3960896 | 0.88 | CCNA2 (0.46) | AXLJAK2JAK3CDK1BRD4 | |
| SCHEMBL3968736 | 0.88 | JAK2 (0.44) | AXLJAK2JAK3YES1EPHB4 | |
| SCHEMBL3967433 | 0.88 | AXL (0.44) | AXLJAK2JAK3CHRNA3HDAC1 | |
| SCHEMBL3967639 | 0.88 | AXL (0.39) | AXLJAK2JAK3YES1EPHB4 | |
| SCHEMBL3968343 | 0.87 | JAK2 (0.52) | AXLJAK2JAK3YES1EPHB4 | |
| SCHEMBL3969931 | 0.87 | CCNT1 (0.45) | AXLJAK2JAK3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |