Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 4/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094730 | 1.00 | FLT3 (0.37) | FLT3MERTKGAS6FGFR1PDK1 | |
| SCHEMBL3967583 | 1.00 | FLT3 (0.37) | FLT3MERTKGAS6FGFR1PDK1 | |
| SCHEMBL4090204 | 0.93 | MERTK (0.41) | FLT3MERTKGAS6FGFR1CCNT1 | |
| SCHEMBL3966717 | 0.93 | FLT3 (0.40) | FLT3MERTKGAS6FGFR1PDK1 | |
| Hydrochloric Acid SCHEMBL3965512 | 0.92 | MERTK (0.40) | FLT3MERTKGAS6FGFR1CCNT1 | |
| SCHEMBL3961904 | 0.92 | MET (0.38) | FLT3MERTKGAS6FGFR1CCNT1 | |
| SCHEMBL3961902 | 0.92 | MET (0.38) | FLT3MERTKGAS6FGFR1CCNT1 | |
| SCHEMBL3965641 | 0.89 | MERTK (0.39) | FLT3MERTKGAS6PDK1PDK2 | |
| Hydrochloric Acid SCHEMBL3962128 | 0.88 | ICAM1 (0.36) | FGFR1PDK1PDK2PDK3PDK4 | |
| Hydrochloric Acid SCHEMBL3962133 | 0.88 | ICAM1 (0.36) | FGFR1PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |