Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Xyloquinone SCHEMBL49964 | 0.76 | PLK1 (0.60) | STAT3PLK1PLK2EEF2KMEN1 | |
| SCHEMBL6449611 | 0.74 | STAT3 (0.69) | STAT3PLK1PLK2EEF2KMEN1 | |
| SCHEMBL16622153 | 0.73 | STAT3 (0.55) | STAT3PLK1PLK2EEF2K | |
| SCHEMBL9875880 | 0.73 | STAT3 (0.37) | STAT3MEN1USP2ALDH1A1GAA | |
| SCHEMBL15396944 | 0.71 | STAT3 (0.77) | STAT3PLK1PLK2EEF2KKDM4E | |
| SCHEMBL9629083 | 0.70 | STAT3 (0.36) | STAT3MAPTTP53IDO1SMN1; SMN2 | |
| SCHEMBL10701770 | 0.69 | STAT3 (0.85) | STAT3 | |
| SCHEMBL14680308 | 0.67 | STAT3 (0.69) | STAT3PLK1PLK2EEF2KMEN1 | |
| SCHEMBL17817858 | 0.67 | STAT3 (0.81) | STAT3PLK1PLK2EEF2K | |
| SCHEMBL7946964 | 0.67 | PLK1 (0.46) | STAT3PLK1PLK2EEF2KMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046127-A1 | DT-DIAPHORASE-ACTIVE AGENTS FOR TREATMENT OF PEDIATRIC TUMORS | ALLOS THERAPEUTICS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| US-20070203109-A1 | Compounds And Compositions For Treatment Of Cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-08-30 | — | — | US | disclosed |
| US-6156744-A | DT-diaphorase directed anti-tumor agents | CANCER RESEARCH CAMPAIGN TECH (LONDON) | 2000-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203109-A1 | Compounds And Compositions For Treatment Of Cancer | RB1, EHMT1, TP53 | STAT3 1625/4885PLK1 1165/4885PLK2 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.