Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.57 |
| ▸ | JAK3 | P52333 | 4/20 | 0.57 |
| ▸ | JAK1 | P23458 | 2/20 | 0.57 |
| ▸ | TYK2 | P29597 | 2/20 | 0.57 |
| ▸ | STAT3 | P40763 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 10/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971207 | 0.90 | CCNA2 (0.63) | JAK2JAK3JAK1BRD4CCNT1 | |
| SCHEMBL3971567 | 0.83 | JAK2 (0.52) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL3975589 | 0.83 | TTK (0.58) | JAK2JAK3JAK1BRD4FLT3 | |
| SCHEMBL3967354 | 0.82 | CCNA2 (0.53) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL3965904 | 0.81 | TNK2 (0.54) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL28322773 | 0.76 | BRD4 (0.56) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL3971558 | 0.73 | TTK (0.47) | JAK2JAK3JAK1BRD4CCNT1 | |
| SCHEMBL30620425 | 0.73 | CDK4 (0.67) | JAK2BRD4CCNA2CDK2CDK9 | |
| SCHEMBL270386 | 0.73 | CDK4 (0.67) | JAK2BRD4CCNA2CDK2CDK9 | |
| SCHEMBL12278146 | 0.72 | BRD4 (0.68) | JAK2BRD4CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |